RESEARCH & OBJECTIVES
Main Objectives of Study
O1. Development of new cationic polymers based on engineered proteins (silk sericin, silk fibroin) by bio-functional modifications
O2. Development of nanocarrier vectors based on engineered protein frameworks
O3. Efficiency evaluation of the non-viral vectors
NANOVEC has ambitious research results that may contribute to the knowledge in the field of cancer gene therapy.
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1. Development of cationic polymers based on engineered proteins by biofunctionalization.
2. Development of polymeric nanocarriers based on engineered protein templates.
3. Development of non-viral vectors containing gene sequences
4. Complex physico-chemical, morphological, structural, in vitro and in vivo evaluation of proteins, modified proteins, nanocarriers and non-viral vectors. These results are very important to gain important knowledge about non-viral vectors.
5. Dissemination of the results by national/international conferences, ISI papers in journals from the field of chemistry, materials, polymers, biomaterials.
6. National patent proposal.
The present project is focused on the development of non-viral vectors based on polymeric nanoparticles for cancer gene therapy (mainly brain cancer). It aims to address a molecular level of gene delivery as a prospective remedial route for this terrible disease. This novel approach offers new insights into gene mutation specific for cancer expression by gene delivery via non-viral vectors. The non-viral vectors are based on specific polymeric nanoparticles with tunable chemistry in order to build specific gene transfection nanocarriers/nano-vectors.